Education:

Work Experience
2016.8 to date Associate Professor of Biochemical Engineering
Department of Chemical and Biochemical Engineering, Xiamen University, China.
2009.9-2016.7 Assistant Professor of Biochemical Engineering
Department of Chemical and Biochemical Engineering, Xiamen University, China.
2015.3-2016.3 Secondment
China National Center for Biotechnology Development, Recognized third-party organization for Scientific Project Management.
2014.7-2014.9 Visiting scholar supported by DAAD
Institute of Bioprocess and Biosystems, Hamburg University of Technology, Germany
2011.9-2012.9 Postdoctoral Fellow
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, USA

Education
2004.9 -2009.9 PhD. Department of Chemical and Biochemical Engineering, Zhejiang University, China.
2000.9 -2004.7 BSc, Department of Chemical Engineering, Fuzhou University, China.

Principal Research Interests:
Biocatalysis and biotransformation; Enzymatic engineering; Biosynthesis of chiral compounds 1.Controlled assembly of multi-enzyme system for biosynthesis. 2.Exploitation of novel enzymes from extremophiles. 3.Biosensor based on functionalized graphene electrode.

Selected Recent Publications:

1.Shi-zhen Wang, Yong-hui Zhang, Hong Ren, Ya-li Wang, Wei Jiang, Bai-shan Fang. Strategies and perspectives of assembling multi-enzyme systems. Critical reviews in biotechnology, accepted, DOI:10.1080/07388551.2017.1303803.

2.Hong Ren, Yong-hui Zhang, Jie-ru Su, Peng Lin, Bo Wang, Bai-shan Fang*, Shi-zhen Wang*.Encapsulation of amine dehydrogenase in hybrid titania nanoparticles by polyethylenimine coating and templatedbiomineralization. Journal of biotechnology, 2017,241:33–41.

3.Yong-hui Zhang, Ya-li Wang, Bei-chu Lin, Shi-zhen Wang*, Bai-shan Fang* Engineering bi-functional enzyme complex of formate dehydrogenase and leucine dehydrogenase by peptide linker mediated fusion for enhancing cofactor channeling. Engineering in life science, accepted, DOI: 10.1002/elsc.201600232.

4.Ji-xueLu,Yong-hui Zhang, Dong-fang Sun, Wei Jiang, Shi-zhen Wang*, Bai-shan Fang*.The development of leucine dehydrogenase and formatedehydrogenase bifunctionalenzyme cascade improves the biosynthsis of L-tert-leucine.Applied Biochemistry and Biotechnology, 2016,180:1180-1195.

5.Chun-jie Zhu, Bai-shan Fang*, Shi-zhen Wang. Effects of culture conditions on the kinetic behavior of 1,3-propanediol fermentation by Clostridium butyricum with a kinetic model. Bioresource Technology, 2016, 212: 130-137.

6.Yong-hui Zhang, Hong Ren, Ya-li Wang, Kai-Nan Chen, Bai-shan Fang*, Shi-zhen Wang*. Bioinspired immobilization of glycerol dehydrogenase by metal ion-chelated polyethyleneimines as artificial polypeptides. Scientific Report, 2016, 6, 24163doi:10.1038/srep24163.

7.Wei Jiang, Shi-zhen Wang, Yuan-peng Wang, Bai-shan Fang*. Key enzymes catalyzing glycerol to 1,3-propanediol.Biotechnology for Biofuels, 2016, 9 :57

8.Bai-shan Fang, Wei Jiang, Qiang Zhou, Shi-zhen Wang*. Codon-optimized NADH oxidase gene expression and gene fusion with glycerol dehydrogenase for bienzyme system with cofactor regeneration. PLoS ONE, 2015, 10: DOI: 10.1371/journal.pone.0128412.

9.Shi-zhen Wang, Long-hui Qiu, Hong-fei Dai, Xiao-fei Zeng, Bai-shan Fang*.Highly pure 1,3-propanediol: Separation and purification from crude glycerol-based fermentation. Engineering in Life Sciences, 2015,15:788–796

10.WeiJiang, Dong-fang Sun, Ji-xue Lu, Ya-li Wang, Shi-zhen Wang, Yong-hui Zhang, Bai-shan Fang*. A cold-adapted leucine dehydrogenase from marine bacteriumAlcanivoraxdieselolei: characterization and L-tert-leucine production. Engineering in Life Sciences,2016, 16: 283–289

11. Wei Jiang, Shi-zhen Wang (Co-first author), Zhong-li Yang, Bai-shan Fang*.B₁₂–independent glycerol dehydratase and its reactivase from Clostridia butyricum: Optimizing cloning by uniform design logic. Engineering in life science, 2015,15:519–524.

12.Wei Jiang, Yuan Zhuang, Shi-zhen Wang, Bai-shan Fang. Directed evolution and resolution mechanism of 1, 3-propanediol oxidoreductase from Klebsiellapneumoniaetoward higher activity by error-prone PCR and bioinformatics. PLoS ONE. 2015, 10: e0141837.

13. Bai-shan Fang, JinNiu, Hong Ren, Ying-xiaGuo, Shi-zhen Wang*. Mechanistic study ofmanganese-substituted glycerol dehydrogenase using a kinetic and thermodynamic analysis. PLoS ONE, 2014, 9(6): e99162

14. Shi-zhen Wang, Hong-fei Dai, Zheng-ping Yan, Chun-jie Zhu, Ling-feng Huang, Bai-shan Fang*.1,3-Propanediol adsorption on a cation exchange resin: Adsorption isotherm, thermodynamics and mechanistic studies. Engineering in Life Sciences, 2014, 14: 485–492.

15. Shi-zhen Wang, Jing Wang, Xiao-fen Zhou, Ying-xiaGuo, Bai-shan Fang*. The improvement of stability, activity and substrate promiscuity of glycerol dehydrogenase substituted by divalent metal ions. Biotechnology and Bioprocess Engineering, 2013,18:796–800.

16. Yi-Qiang Peng, Shi-zhen Wang, Ling Lan, Wei Chen, Bai-Shan Fang*.Resin adsorption application for product separation and catalyst recycling in coupled enzymatic catalysis to produce 1,3-propanediol and dihydroxyacetone for repeated batch. Engineering in Life Sciences, 2013, 13: 479–486.

17. Wei-wei Wen, Shi-zhen Wang(Co-first author), Xiao-fen Zhou, Bai-shan Fang*, Central carbon metabolism in marine bacteria examined with a simplified assay for dehydrogenases. Applied Biochemistry and Biotechnology, 2013,170: 473–482.

18. Shi-zhen Wang, Jian-ping Wu*, Gang Xu, Li-rong Yang. Chemo-enzymatic asymmetric synthesis of S-citalopram by lipase-catalyzed cyclic resolution and stereoinversion of quaternary stereogenic center. Bioprocess and Biosystems Engineering, 2013,36:1031–1037.

19. Shi-zhen Wang, Jian-ping Wu, Gang Xu, Li-rong Yang*, Kinetic and thermodynamic study of lipase-catalyzed remote resolution of a chiral tertiary alcohol. Biochemical Engineering Journal, 2012,65:57–62.

20. Shi-zhen Wang, Jian-ping Wu, Gang Xu, Li-rong Yang*, Lipase-catalyzed remote kinetic resolution of citalopram intermediate by asymmetric alcoholysis and thermodynamic analysis, Bioprocess and Biosystems Engineering, 2012,35: 1043–1048.

21. Shi-zhen Wang and Bai-shan Fang*, Microplate bioassay for determining substrate selectivity of Candida rugosa lipase, Journal of Chemical Education, 2012, 89: 409–411.