名师讲座
报告题目：Biosensors based on aptamers and gold nanoparticles
报告时间：2024-05-07 10:00
报告人： 刘珏文教授
University of Waterloo
报告地点：卢嘉锡202报告厅
转播地点：翔安校区能源材料大楼3号楼会议室5，漳州校区生化主楼307教室
报告摘要：
Interfacing DNA with gold nanoparticles (AuNPs) has produced a diverse range of biosensors, imaging agents, drug delivery systems, and new materials. AuNPs are particularly attractive because of their low toxicity and unique optical, electric and catalytic properties. Using fluorescently labeled oligonucleotides as probes, we measured the kinetics of DNA adsorption, desorption as well as adsorption isotherm as a function of salt, pH, and temperature. An important application of such fundamental studies is the attachment of DNA to AuNPs. Highly efficient DNA adsorption can be achieved at low pH and freezing. In addition, we studied aptamer-based sensors using AuNPs for signal production and revealed some potential artifacts. In the second part of the talk, our recent work on selection of DNA aptamers for binding to small molecular targets will be presented.
报告人简介：
Juewen Liu received his Bachelor’s degree from the University of Science & Technology of China in 2000 and Ph.D. from the University of Illinois at Urbana-Champaign in 2005. He joined the University of Waterloo in 2009 and is currently a professor of chemistry. He is interested in aptamers and biosensors. He received a Fred Beamish Award (2014) and a McBryde Medal (2018) from the Canadian Society for Chemistry for his contribution in bioanalytical chemistry. He serves as a Section Editor for Biosensors & Bioelectronics, and a Contributing Editor for TrAC Trends in Analytical Chemistry. He has published over 400 papers, receiving over 40,000 citations with an H-index of 98, and is a Clarivate Highly Cited Researcher in 2022.
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