颜晓梅

个人简历：

学士（厦门大学科学仪器工程系，1990）

博士（厦门大学化学系，1996，日本名古屋大学联合培养）

博士后（美国佛罗里达大学化学系，1996-1997）

博士后、研究员（美国Los Alamos国家实验室生物科学部，1997-2005）

近年主持主要科研项目包括：国家重大科研仪器研制项目、国家自然科学基金委重点项目、国家杰出青年科学基金、国家自然科学基金委面上项目等。

先后获得教育部新世纪优秀人才支持计划、国家杰出青年科学基金、福建省高校领军人才、福建省科技创新领军人才、厦门市五一劳动奖章、第十二届福建青年科技奖、科技部中青年科技创新领军人才、中国女分析化学家奖、厦门市双百计划领军型创业人才A+、国家科技创新领军人才、厦门市科技进步一等奖、首批厦门市杰出人才、福建省高层次人才A类等奖项与称号。

研究兴趣：

1. 纳米流式检测技术的研发及其在生命科学、生物医药、食品安全、环境监测、能源材料领域中的应用

2. 单分子、单颗粒、单细胞测量与分析

3. 液相芯片技术的开发及其生化分析、生物医学应用等

近期主要代表论著：

1. 1. Chen, CX; Zhou, YX; Chen, C; Zhu, SB; Yan, XM*; Quantification of Available Ligand Density on the Surface of Targeted Liposomal Nanomedicines at the Single-Particle Level, ACS Nano 2022, 16, 6886-6897.

2. 2. Liu, HS; Tian, Y; Xue, CF; Niu, Q; Chen, C; Yan, XM*; Analysis of Extracellular Vesicle DNA at the Single-Vesicle Level by Nano-flow cytometry, J. Extracell. Vesicles 2022, 11, e12206.

3. 3. Niu, Q;^# Ma, L;^# Zhu, SB; Li, L; Zheng, QS; Hou, JB; Lian, H; Wu, LN; Yan, XM*; Quantitative Assessment of the Physical Virus Titer and Purity by Ultrasensitive Flow Virometry, Angew. Chem. Int. Ed. 2021, 60, 9351-9356.

4. 4. Chen, CX;* Sun, MD; Wang JL; Su, LY; Lin, JJ; Yan, XM*; Active Cargo Loading into Extracellular Vesicles: Highlights the Heterogeneous Encapsulation Behavior, J. Extracell. Vesicles 2021, 10, e12163.

5. 5. Gao, KM;^# Zhou, YX;^# Lu, QY; Lu, JY; Su, LY; Su, R; Zhang, MM; Tian, Y; Wu, LN; Yan, XM*; High-Throughput Human Telomere Length Analysis at the Single-Chromosome Level by FISH Coupled with Nano-Flow Cytometry. Anal. Chem. 2021, 93, 9531-9540.

6. 6. Tian, Y; Gong, MF; Hu, YY; Liu, HS; Zhang, WQ; Zhang MM; Hu, XX, Aubert, D; Zhu, SB; Wu, LN; Yan, XM*; Quality and Efficiency Assessment of Six Extracellular Vesicle Isolation Methods by Nano-Flow Cytometry, J. Extracell. Vesicles 2020, 9, 1697028 (ESI高被引论文)

7. 7. He, SB; Hong, XY; Zhang, MM; Wu, LN; Yan, XM*; Label-Free Detection of Bacteria in Fruit Juice by Nano-Flow Cytometry, Anal. Chem. 2020, 92, 2393-2400.

8. 8. Lian, H; He, SB; Chen, CX; Yan, XM*; Flow Cytometric Analysis of Nanoscale Biological Particles and Organelles, Annu. Rev. Anal. Chem. 2019, 12, 389-409.

9. 9. Tian, Y; Ma, L; Gong, MF; Su, GQ*, Zhu, SB; Zhang, WQ; Wang, S; Li ZB; Chen CX; Li, LH; Wu, LN; Yan, XM*; Protein Profiling and Sizing of Extracellular Vesicles from Colorectal Cancer Patients via Flow Cytometry, ACS Nano 2018, 12, 671-680 (ESI高被引论文)

10. 10. Zhang, WQ; Tian, Y; Hu, XX; He, SB; Niu, Q; Chen, CX; Zhu, SB; Yan, XM*; Light-Scattering Sizing of Single Submicron Particles by High-Sensitivity Flow Cytometry, Anal. Chem. 2018, 90, 12768-12775.

11. 11. Wang, S; Li, LH; Jin, SH; Li, WF; Hang, W; Yan, XM*; Rapid and Quantitative Measurement of Single Quantum Dots in a Sheath Flow Cuvette, Anal. Chem. 2017, 89, 9857-9867.

12. 12. Wu, LN; Wang, X; Zhang, JQ; Luan, T; Bouveret, E.; Yan, XM*; Flow Cytometric Single-Cell Analysis Enables Quantitative in vivo Detection of Protein-Protein Interactions via Relative Reporter Protein Expression Measurement, Anal. Chem. 2017, 89, 2782-2789.

13. 13. Chen, CX; Zhu, SB; Wang, S; Zhang, WQ; Cheng, Y; Yan, XM*; Multiparameter Quantification of Liposomal Nanomedicines at the Single-particle Level by High Sensitivity Flow Cytometry, ACS Appl. Mater. Interfaces 2017, 9, 13913-13919.

14. 14. Ma, L^#; Zhu, SB^#; Tian, Y; Zhang, WQ; Wang, S; Chen, CX; Wu, LN; Yan, XM*; A Label-Free Analysis of Single Viruses with a Resolution Comparable to That of Electron Microscopy and the Throughput of Flow Cytometry, Angew. Chem. Int. Ed. 2016, 55, 10239 –10243. (Hot Paper)

15. 15. Zhu, SB; Ma, L; Wang, S; Chen, CX; Zhang, WQ; Yang, LL; Hang, W; Nolan, J. P.; Wu, LN; Yan, XM*; Light-Scattering Detection below the Level of Single Fluorescent Molecules for High-Resolution Characterization of Functional Nanoparticles. ACS Nano 2014, 8, 10998-11006.

纳米流式检测技术的研发与应用