Office: LU Jia-xi Building 528　
Tel: 2180278　
Email: jhgao@xmu.edu.cn
Address: State Key Laboratory of Physical Chemistry of Solid Surfaces

Education:
B.S., Chemistry, Nanjing University, China　( 2000 - 2004 )
Ph.D., Chemistry, HKUST, Hong Kong, China　( 2004-2008 )

Principal Research Interests:
Our research interests are focused on the design of biofunctional nanomaterials and their applications in biology and medicine, such as biosensors, cell biology, drug delivery, molecular imaging, and cancer therapy.

Selected Recent Publications:

1. 1. Chen, D.; Guo, J.; Li, A.; Sun, C.; Lin, H.; Lin, H.*; Yang, C.*; Wang, W.*; Gao, J. H.* Metabolic Fluorine Labeling and Hotspot Imaging of Dynamic Gut Microbiota in Mice. Science Advances 2023, 9, eabg6808.

2. 2. Luo, X.; Gong, X.; Su, L.; Lin, H.; Yang, Z.; Yan, X.; Gao, J. H.* Activatable Mitochondria-Targeting Organoarsenic Prodrugs for Bioenergetic Cancer Therapy. Angew. Chem. Int. Ed. 2021, 60, 1403-1410.

3. 3. Lin, H. Y.; Tang, X.; Li, A.; Gao, J. H.* Activatable ¹⁹F MRI Nanoprobes for Visualization of Biological Targets in Living Subjects. Adv. Mater. 2021, 33, 2005657.

4. 4. Zhu, X. L.; Tang, X.; Lin, H. Y.; Shi, S.; Xiong, H.; Zhou, Q.; Li, A.; Wang, Q.; Chen, X.; Gao, J. H.* A Fluorinated Ionic Liquid-Based Activatable ¹⁹F MRI Platform Detects Biological Targets. Chem 2020, 6, 1134-1148.

5. 5. Sun, C. J.; Lin, H. Y.; Gong, X. Q.; Yang, Z.; Mo, Y.; Chen, X.; Gao, J. H.* DOTA-Branched Organic Frameworks as Giant and Potent Metal Chelators. J. Am. Chem. Soc. 2020, 142, 198-206.

6. 6. Tang, X.; Li, A.; Zuo, C.; Liu, X.; Luo, X.; Chen, L.; Li, L.; Lin, H.*; Gao, J. H.* Water-Soluble Chemically Precise Fluorinated Molecular Clusters for Interference-Free Multiplex ¹⁹F MRI in Living Mice. ACS Nano 2023, 17, 5014-5024.

7. 7. Jiang, Y.; Luo, X.; Chen, L.; Lin, H.*; Gao, J. H.* Multicolor ¹⁹F magnetic resonance imaging: A promising medical technique for in vivo visualization of multiple biological targets. Fundamental Research 2023, 3, 529-533.

8. 8. Liu, K.; Cai, Z.; Chi, X.; Kang, B.; Fu, S.; Luo, X.; Lin, Z.-W.; Ai, H.*; Gao, J. H.*; Lin, H.* Photoinduced Superhydrophilicity of Gd-Doped TiO2 Ellipsoidal Nanoparticles Boosts T₁ Contrast Enhancement for Magnetic Resonance Imaging. Nano Lett. 2022, 22, 3219-3227.

9. 9. Sun, C. J.; Yang, Z. X.; Wu, P.; Luo, X. J.; Liu, K.; Wang, B. J.; Lin, H. Y.*; Gao, J. H.* Multinuclear Mn(II) United-DOTA Complexes with Enhanced Inertness and High MRI Contrast Ability. Cell Rep. Phys. Sci. 2022, 3, 100920.

10. 10. Yang, Z. X.; Luo, X. J.; Lin, Y. Y.; Huang, J. Q.; Lin, H. Y.*; Gao, J. H.* Tandem Chemoimmunotherapy by a Cascade-Responsive Molecular Prodrug. ACS Chem. Biol. 2022, 17, 762-767.

11. 11. Liu, K.; Kang, B.; Luo, X.; Yang, Z.; Sun, C.; Li, A.; Fan, Y.; Chen, X.; Gao, J. H.*; Lin, H.* Redox-Activated Contrast-Enhanced T₁-Weighted Imaging Visualizes Glutathione-Mediated Biotransformation Dynamics in the Liver. ACS Nano 2021, 15, 17831-17841.

12. 12. Tang, X.; Gong, X. Q.; Li, A.; Lin, H. Y.; Peng, C.; Zhang, X.; Chen, X.; Gao, J. H.* Cascaded Multiresponsive Self-Assembled ¹⁹F MRI Nanoprobes with Redox-Triggered Activation and NIR-Induced Amplification. Nano Lett. 2020, 20, 363-371.

13. 13. Zhou, Z.; Yang, L.; Gao, J. H.*; Chen, X.* Structure–Relaxivity Relationships of Magnetic Nanoparticles for Magnetic Resonance Imaging. Adv. Mater. 2019, 31, 1804567.

14. 14. Zhang, Y. J.*; Zhang, L.; Gao, J. H.*; Wen, L. P.* Pro-Death or Pro-Survival: Contrasting Paradigms on Nanomaterial-Induced Autophagy and Exploitations for Cancer Therapy. Acc. Chem. Res. 2019, 52, 3164-3176.

15. 15. Wei, R.; Gong, X.; Lin, H.; Zhang, K.; Li, A.; Liu, K.; Shan, H.; Chen, X.; Gao, J. H.* Versatile Octapod-Shaped Hollow Porous Manganese(II) Oxide Nanoplatform for Real-Time Visualization of Cargo Delivery. Nano Lett. 2019, 19, 5394-5402.

16. 16. Zhou, Z.; Wu, C.; Liu, H.; Zhu, X.; Zhao, Z.; Wang, L.; Xu, Y.; Ai, H.; Gao, J. H.* Surface and Interfacial Engineering of Iron Oxide Nanoplates for Highly Efficient Magnetic Resonance Angiography. ACS Nano 2015, 9, 3012-3022.

17. 17. Zhao, Z.; Wang, X.; Zhang, Z.; Zhang, H.; Liu, H.; Zhu, X.; Li, H.; Chi, X.; Yin, Z.; Gao, J. H.* Real-Time Monitoring of Arsenic Trioxide Release and Delivery by Activatable T₁ Imaging. ACS Nano 2015, 9, 2749-2759.

18. 18. Zhou, Z.; Zhao, Z.; Zhang, H.; Wang, Z.; Chen, X.; Wang, R.; Chen, Z.; Gao, J. H.* Interplay between Longitudinal and Transverse Contrasts in Fe₃O₄ Nanoplates with (111) Exposed Surfaces. ACS Nano 2014, 8, 7976-7985.

19. 19. Zhao, Z. H.; Zhou, Z. J.; Bao, J. F.; Wang, Z. Y.; Hu, J.; Chi, X. Q.; Ni, K. Y.; Wang, R. F.; Chen, X. Y.; Chen, Z.; Gao, J. H.* Octapod Iron Oxide Nanoparticles as High-Performance T₂ Contrast Agents for Magnetic Resonance Imaging. Nat. Commun. 2013, 4, 2266.

20. 20. Zhou, Z. J.; Huang, D. T.; Bao, J. F.; Chen, Q. L.; Liu, G.; Chen, Z.; Chen, X. Y.; Gao, J. H.* A Synergistically Enhanced T₁-T₂ Dual-Modal Contrast Agent. Adv. Mater. 2012, 24, 6223-6228.